- Place pharmacokinetic properties in Lead Compound, Candidate Drug and Target
Product Profiles
- Understand in vitro and in vivo clearances
- Interpret half-life, bioavailability and tissue/body space distribution data
- Evaluate in vitro drug interaction data
- Interpret physicochemical data in relation to Pharmacokinetics
- Evaluate a target metabolic/pharmacokinetic profile
- Differentiate pharmacokinetic and pharmacodynamic factors in drug response
- Perform extrapolations from animals to humans
- Communicate successfully in meetings involving project scientists and
pharmacokineticists.
CONTENT
The workship will address the optimal integration of Pharmacokinetics into the Drug
Discovery and Preclinical Development process from early Lead Generation to Clinical
Proof of Principle (Phase I or II). Participants will:
- Study the context in which pharmacokinetic data can be utilized.
- Develop their understanding of the key concepts of clearance, half-life,
bioavailability, and apparent volume of distribution.
- Analyze the relationship between in vitro and in vivo experiments in which
clearance values are measured.