- Evaluate the importance of linear kinetics as a project goal.
- Design a pharmacokinetic specification of the "perfect" drug taking into
account other project goals and the planned clinical application.
- Learn to position pharmacokinetic data in a target product profile.
- Consider potential later issues, such as drug interactions in multiple drug
therapy, and disease and environmental factors in drug response.
- Practice the integration of pharmacokinetics and pharmacological testing.
The workshop will incorporate presentations, discussion sessions and class/small
group exercises. The style of the workshop will be highly interactive.
AGENDA
Day I: Introductions
The Pharmacokinetic Processes (ADME etc.)
Clearance Concepts In Vitro and In Vivo
Extrapolation from In Vitro to In Vivo
Intravenous and Oral Dosing
Strategy Session: Incorporation of DMPK Data into Candidate Drug Selection
Special Issues of Proteins and Peptides
Exercises